Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, mukaadial and ugandensial, flavonoids and miscellaneous compounds present in the various species. Warburgia ugandensis phytochemical research projectifs research. This data set contains scores for 185 loci for 100 individuals of the warburgia ugandensis tree species a medicinal tree species native to eastern africa. Warburgia ugandensis, also known as ugandan greenheart, is a species of evergreen tree native to africa. Ms, drimane sesquiterpenes, sugars and sugar alcohols, were compared with bacterial and fungal endophyte communities trflp, dna clones, qpcr in leaves and roots of the pepper bark tree, warburgia ugandensis canellaceae. Commercial maize has been selectively bred to produce high quantities of. Wood anatomy of pleodendron costaricense canellaceae. Acetylugandensolide and antimicrobial properties of warburgia ugandensis extracts and isolates against sweet potato pathogens. Warburgia ugandensis medicinal herb used for the treatment of diabetes, malaria and pneumonia in kisii region, southwest kenya global journal of pharmacology.
Most of the african counties in which the plant species is found include. A comparative study of the stem bark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w. Warburgia ugandensis bioassay of different plant parts concerning. Compositae and chasmanthera dependens hoschst family.
A drimane sesquiterpenoid lactone from warburgia salutaris. Plant extracts from warburgia ugandensis sprague family. The stem and roots of warburgia ugandensis sprague are used as expectorant, for the common cold and against fever, malaria, stomachache, constipation and diarrhea 1, 2. Warburgia ugandensis sprague canellaceae, which is commonly known as zogdom in amharic, is characterized by its bitter and peppery taste. Kowalski and van staden 2001 and prunus africana are exploited, while the rhizome of alepidea amatymbica is used cunningham 1993. Abraham abebe wube1, simon gibbons2, kaleab asres3, bernhard streit1, michael adams1, rudolf bauer1, franz bucar1 1 institute of pharmaceuticalsciences, department of pharmacognosy, university graz, of graz, austria. This study describes an efficient regeneration protocol. Although locally common in some areas, the populations of this species have been wiped out in many areas due to the use of its bark by traditional healers for medicinal purposes against asthma, maralia and other ailments as well as skin cream. An efficient callusbased in vitro regeneration protocol for. Preliminary phytochemical analysis of leaf powder extracts. Kenya,ethiopia and some parts of western africa the wood is resistant to insect attack and very strong.
Warbugia ugandensis kenya neem foundation herbal clinic. Pdf a phytochemical basis for the potential use of. Pdf warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued. Canellaceae is an important, overexploited african ethnomedicinal plant threatened with extinction in the wild. Evidence for alteration of fungal endophyte community. Warburgia canellaceae species have a long history of ethnomedicinal uses in east, central and southern africa. Antimicrobial and cytotoxic activities of fresh leaf extracts of warburgia ugandensis z. Sesquiterpenes from warburgia ugandensis and their. In vitro 12shete and leukotriene metabolism inhibitory activity of sesquiterpenes of warburgia ugandensis. The wood is resistant to insect attack and very strong.
I56230552011 a thesis submitted in partial fulfillment of the requirements for the award of the degree of master of science biotechnology in the school of pure and applied. Phytochemical tests in our laboratories indicated the presence of tannins. Phytochemical analysis of warburgia ugandensis sprague using fourier transform infrared ftir spectroscopy. Warburgia ugandensis water extracts and fraction 27163d also showed antifungal activity against candida albicans. In silico validation of two antiparasitic acetogenins 26 sl 32 mulaa, francis j. Warburgia ugandensis, also known as uganda greenheart, is a species of evergreen tree native to africa. Warburgia ugandensis, sprague, also known as the east african greenheart, a canallaceae, is a species of evergreen tree common to east african forests7. Warburgia ugandensis sprague, which belongs to a member of canellaceae family, is a small evergreen tree distributed in eastern and southern africa. Canaleaceae, also known as the east african greenheart, is a species of evergreen tree native to africa and a highly. Abstract arun arora, deepak mahapatra, fourier transform infrared spectroscopy analysis of few medicinal plants of. Dragons blood is the name given to a deep red resin obtained from a variety of plant sources. Warburgia ugandensis sprague canellaceae extracts from different populations across the kenyan rift valley abuto john otieno b. Warburgia ugandensis health effects and herbal facts. Warburgia ugandensis bioassay of different plant parts concerning the antimicrobial.
Diversity in the phytochemical profiles of warburgia. Pdf warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. Due to overexploitation for its medicinal uses, the. Abstract warburgia ugandensis is a highly valued medicinal tree within east africa which is overexploited for its medicinal use among. In traditional chinese medicine, this resinous medicine is commonly prescribed to invigorate blood. Stuhlmann collected warburgia from mpizi near pangani in the then tanganyika and named it w. Antimicrobial and cytotoxic activities of fresh leaf extracts. Bioassayguided studies on the cytotoxic and in vitro. Ten individuals each were assessed from two locations east and west of the great rift valley, kenya, africa, which differed in humidity and. The cytotoxicity of the drugs on balbc peritoneal macrophage cells was insignificant as compared to the highly toxic drug of choice pentostam. Warburgia ugandensis is a multipurpose tree which is highly beneficial for its pharmaceutical properties and is. Phytochemistry and pharmacological studies on solanum. The resin extracted from stems of dracaena cochinchinensis is one such source of dragons blood. Warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued medicinal plant in traditional medicine with a broad spectrum of antimicrobial activity whose parts especially the leaves and stem bark have for long been used in the treatment and management of many diseases and health conditions such as stomachache, cough, toothache.
Ethnopharmacological potentials of warburgia ugandensis on. The ability of warburgia salutaris extracts to protect. This tree species is also found in india and china 1, 3. Sabinet a phytochemical basis for the potential use of. Warburgia ugandensis extracts were generally more toxic table 2. In vitro 12shete and leukotriene metabolism inhibitory. Initially, verdcourt thought that the specimen was conspecific with w. Diversity in the phytochemical profiles of warburgia ugandensis. Various parts fruit, leaves and roots are being in use for the isolation of a wide range of compounds. Warburgia is a genus of plant in family canellaceae described as a genus in 1895. Warburgia ugandensis sprague family canellaceae, commonly referred to as east african greenheart pepperbark tree is widely distributed in the lowland rainforests and upland dry evergreen forests of eastern and southern africa 1.
Alice njeri muchugi 5 on rooting and shoot formation of warburgia ugandensis stem cuttings african journal of plant science vol. Pdf diversity in the phytochemical profiles of warburgia. Extracts of warburgia ugandensis have been reported to show some antimalarial properties in animal models. In southern africa, the medicinal plant warburgia salutaris is commonly used for the treatment of inflammatory and other diseases.
Jan 22, 2019 warburgia ugandensis sprague is a woody species in the family canellaceae and an important source of medicines in africa. Frontiers antimicrobial drimane sesquiterpenes and their. In subsaharan africa, chronic kidney disease ckd is being recognized as a noncommunicable disease ncd with high morbidity and mortality. In vitro effects of warburgia ugandensis, psiadia punctulata and chasmanthera dependens on leishmania major promastigotes. Warburgia ugandensis, psiadia punctulata and chasmanthera dependens had an ic50 of 1.
Pdf phytochemical analysis of warburgia ugandensis sprague. Phytochemistry solanum torvum has been extensively explored for its chemical constituents. Screening of extracts of zanthoxylum chalybeum and warburgia. Kadu cac, schueler s, konrad sh, muluvi gm, eyogmatig o, muchugi a, williams vl, ramamonjisoa l, kapinga c, foahom b, katsvanga c, hafashimana d, obama c and. It has a reputation for facilitating blood circulation and dispersing blood stasis. The stem bark has been widely used in east african ethnomedicine for the treatment of stomachache, constipation, toothache, cough, fever, muscle pains, weak joints and general body pains kokwaro, 1976, watt and breyerbrandwijk, 1962. One new drimanetype sesquiterpenoid, named ugandenial a 1, was isolated from the ethyl acetate extract of the bark of warburgia ugandensis canellaceae together with eight known drimanetype sesquiterpenoids. Its allelophathic nature can drastically reduced the crop production and aggressive dominance of this weed threatens. Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83 nlb144 and infected macrophages in vitro. Warburgia ugandensis in plasmodium berghei infected mice ournal of pharmacognosy and phytochemistry issn. Commercial maize has been selectively bred to produce high quantities of defense compounds, the benzoxazinoids bxs. The tree species also occurs in secondary bushlands, grasslands and termitaria. In vitro effects of warburgia ugandensis, psiadia punctulata. A comparative study of the stembark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w.
Warburgia bark has been commonly used as traditional medicines for the treatment of gastrointestinal disorders, cold, cough and sore throat, fever, malaria, respiratory and odontological problems in african countries. Gane sent a warburgia specimen from the present tanzania to verdcourt 1954 that had foliage similar to w. Warburgia ugandensis is commonly known as east african green woodgreenheartpepper bark tree and it is in the family canellaceae 23. This species has its habitat encroached and this has led to a notable decrease in its population size to the level that warrant some conservation efforts. The spatial scale of influence may increase when plant defense compounds are secreted in soil, affecting colonization by mycorrhizal and soil fungi stinson et al. The presence of biologically active drimane sesquiterpenoid lactone constituents in the leaves, here demonstrated, provides the rational basis for their substitution for bark in ethnomedicine. Pdf toxicology, phytochemistry, bioactive compounds and. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa stem bark powder is known to be active against microbes olila et al. Polygodial, an antifungal potentiator journal of natural. Warburgia ugandensis kenyatta university repository.
Warburgia ugandensis bioassay of different plant parts. Phytochemical analysis of warburgia ugandensis sprague. It was commonly used for the yoke pole of oxwagons, the disselboom. Warburgia ugandensis isa highly valuedmedicinal tree within east africa which is overexploited for its medicinal use among many communities. This weed is considered to be a cause of a spectrum of clinical patterns. Traditional medicine practices among community members with. Warburgia ugandensis is one of the ten species identified as high priority medicinal plants in kenya for detailed study. Applications of phytochemical and in vitro techniques for. Petiole bases and shoot tips were used as explants. Molecules free fulltext ugandenial a, a new drimanetype. Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83. Variation in antimicrobial activity of warburgia ugandensis. Due to over exploitation for its medicinal uses, the. International journal of pharmacognosy and phytochemical research 2014.
Since the data set is a subset of a larger data set that originated from a study of several warburgia species, some of the loci did not produce bands for w. Safety and efficacy of prunus africana and warburgia. Antibacterial and antifungal activities of extracts of. Warburgia ugandensis is an evergreen tree with a spreading, rounded crown. Chromatography of extracts of warburgia ugandensis stem bark afforded compound 49169k, which was characterized as the sesquiterpine muzigadial by 1 hnmr spectroscopy, which did not show antibacterial activity but had. A phytochemical basis for the potential use of warburgia salutaris pepperbark tree leaves in the place of bark article pdf available january 2001 with 456 reads how we measure reads. Warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. The sugar alcohol mannitol 3% has been reported as present gr1.
Phytochemical analysis of warburgia ugandensis sprague using. In countries like tanzania, people access many sources, including traditional medicines, to meet their healthcare needs for ncds, but little is known about traditional medicine practices among people with ckd. A model for antimalarial drugs discovery 24 sl 30 robert byamukama cycloartane triterpenes from the leaves of neoboutonia macrocalyx l. Parthenium hysterophorus, members of the asteraceae family is a noxious weed in america, asia, africa and australia. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa.
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